Generally, we would recommend taking this product during the morning and afternoon, preferably before exercising. Although 7-Keto^® Lean is not a stimulant, we feel it is better to avoid taking this product at night as it contains herbs to support fluid balance that are best used in the daytime. Additionally, metabolism tends to be more active in the daytime. Some people may experience mild gastrointestinal upset, in which case we suggest taking 7-Keto^® Lean with food. However, this is a personal preference.

7-Keto Lean™ (#15163) is a dietary supplement designed for weight loss. It contains 7-Keto DHEA and seven other ingredients which support healthy weight management and metabolism. and metabolism. Safety assessment has reported that 7-Keto DHEA is not mutagenic. No adverse effects were observed either clinically or anatomically, in oral acute or subacute toxicity evaluations in animals, when 7-Keto DHEA is administered.^1-3 Human studies have also shown that administration of 7-Keto DHEA up to 200 mg/day does not produce clinically important hormone (testosterone, dihydrotestosterone, estradiol, cortisol, and insulin) changes.^4,5 In addition, 7-Keto DHEA is well-tolerated with no adverse effects reported during an 8-week study.⁵ Furthermore, the amounts of copper, manganese, iodine, and L-tyrosine in 7-Keto Lean™ are within the range of Recommended Dietary Allowances (RDA).⁶Cardizem® and Prilosec® are prescription drugs. Cardizem® is indicated for the management of chronic stable angina and angina due to coronary artery spasm, while Prilosec® is indicated for the treatment of short-term active duodenal ulcer.⁷

To date, we are unable to locate any information regarding sleeplessness associated with 7-Keto DHEA or any ingredient in 7-Keto Lean™. However, we have forwarded this question to Dr. John L. Zenk, M.D., Chief Medical and Scientific Director, Humanetics Corporation (the manufacturer of 7-Keto™), who responded:⁸

We have had no universal complaints regarding insomnia with 7-Keto. We have had reports of vivid dreams (not nightmares) which do not translate to sleeplessness, but may be increasing REM sleep (rapid eye movement sleep) which is "dream sleep". People who spend much of their night in REM sleep eventually may feel tired during the day due to a lack of Stage III and IV sleep, the deeper stages of sleep. What I have suggested and what seems to be working well is that people do not take their 7-Keto right before bedtime, but rather at least 4 hours before retiring. Therefore, if they are taking 7-Keto twice daily, I have suggested a dosing schedule of 8 AM and 5 PM.

Additionally, sleep difficulties can be indicative of an underlying physical problem and should be evaluated by a licensed healthcare practitioner if the problem persists.

DHEA (dehydroepiandrosterone) is a steroid hormone produced by the adrenal glands, which plays a role in healthy aging, immune function, and memory.† In the body, DHEA can form sex hormones (estrogen and testosterone) and 7-Keto DHEA. 7-Keto DHEA does not convert to sex hormones.† 7-Keto DHEA is safe and well tolerated.

7-Keto^® Lean has only been clinically tested in adults. Because 7-Keto production in the body begins to decline in your late 20’s, 7-Keto^® Lean is most beneficial in individuals 25 years of age and older.

Yes, you can safely take 7-Keto^® Lean with Metabolic Advantage^TM Thyroid Formula†. However, individuals who are sensitive to L-tyrosine should consider reducing the dosage of one or both products (e.g., one capsule of 7-Keto^® Lean daily or two servings of Metabolic Advantage daily).

Losing weight and maintaining a healthy weight requires attention to diet and exercise. There is no quick fix. While 7-Keto^® Lean can help you reach your weight loss goals faster, incorporating healthy lifestyle changes are the key to long-lasting weight maintenance.†

7- Keto DHEA is irreversibly metabolized from DHEA, and it will not convert to DHEA. Therefore, 7-Keto does not raise blood levels of DHEA in the body.